Side Reactions in Peptide Synthesis

Side Reactions in Peptide Synthesis

<i> <p>Side Reactions in Peptide Synthesis, </i>based on the author’s academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. </p> <p>This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. </p> <p>While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay. </p> <p>Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction. </p><ul><li>Provides a systematic examination on how to troubleshoot and minimize the most frequent side reactions in peptide synthesis</li><li>Gives chemists the background information and the practical tools they need to successfully troubleshoot and improve results</li><li>Includes optimization-oriented analysis of side reactions in peptide synthesis for improved industrial process development in peptidyl API (active pharmaceutical ingredient) production </li><li>Answers the growing, global need for improved, replicable processes to avoid impurities and maintain the integrity of the end product.</li><li>Presents a thorough discussion of critical factors in peptide synthesis which are often neglected or underestimated by chemists </li><li>Covers solid phase and solution phase methodologies, and provides abundant references for further exploration</li></ul>