Sample Size Calculations in Clinical Research (Chapman & Hall/CRC Biostatistics Series)

Sample Size Calculations in Clinical Research (Chapman & Hall/CRC Biostatistics Series)

<P>Praise for the Second Edition:</P><I> <P>"… this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study."</I> -<B><I>Biometrics</P></B></I> <P>"<I>This impressive book contains formulae for computing sample size in a wide range of settings. One-sample studies and two-sample comparisons for quantitative, binary, and time-to-event outcomes are covered comprehensively, with separate sample size formulae for testing equality, non-inferiority, and equivalence. Many less familiar topics are also covered …</I>" – <B><I>Journal of the Royal Statistical Society</I></B></P> <P><B>Sample Size Calculations in Clinical Research, Third Edition</B> presents statistical procedures for performing sample size calculations during various phases of clinical research and development. A comprehensive and unified presentation of statistical concepts and practical applications, this book includes a well-balanced summary of current and emerging clinical issues, regulatory requirements, and recently developed statistical methodologies for sample size calculation.</P> <P></P><B> <P>Features:</P> <UL></B> <P> <LI>Compares the relative merits and disadvantages of statistical methods for sample size calculations</LI> <P></P> <P> <LI>Explains how the formulae and procedures for sample size calculations can be used in a variety of clinical research and development stages</LI> <P></P> <P> <LI>Presents real-world examples from several therapeutic areas, including cardiovascular medicine, the central nervous system, anti-infective medicine, oncology, and women’s health</LI> <P></P> <P> <LI>Provides sample size calculations for dose response studies, microarray studies, and Bayesian approaches</LI> <P></P></UL> <P></P> <P>This new edition is updated throughout, includes many new sections, and five new chapters on emerging topics: two stage seamless adaptive designs, cluster randomized trial design, zero-inflated Poisson distribution, clinical trials with extremely low incidence rates, and clinical trial simulation.</P> <P></P> <P> </P>