Pharmaceutical Process Development: Current Chemical and Engineering Challenges (Drug Discovery Series, Volume 9)
Pharmaceutical process research and development is an exacting, multidisciplinary effort but a neglected discipline in the chemical curriculum. This book presents an overview of process development and how recent advances in synthetic organic chemistry, process technology and chemical engineering have impacted on the manufacture of pharmaceuticals. The concise chapters cover such diverse subjects as route selection and economics, the interface with medicinal chemistry, the impact of green chemistry, safety, the crucial role of physical organic measurements in gaining a deeper understanding of chemical behaviour, the role of the analyst, new tools and innovations in reactor design, purification and separation, solid state chemistry and its role in formulation and ends with an assessment of future trends and challenges.